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The effect of an IUD on serum and secretory immunoglobulins IgA IgG IgM and alpha-2-macroglobulin were estimated on agar gel for 20 women using an IUD and 10 controls not using an IUD. There was an increase in IgG (.02<P<.05) in women using IUDs. Large molecular weight proteins were found more frequently in uterine fluid aspirate of women using IUDs. IgA amounts were greater than would be expected from passive filtration from vascular permeability. This was true of IgG in 16 of 20 women and IgM in 13 of 20 women. These results suggest that secretory immunoglobulins may play a significant role in physiopathological mechanisms associated with the contraceptive action of IUDs.

LEVELS OF IMMUNOGLOBULINS IN THE SERUM AND UTERINE FLUID OF WOMEN USING AN INTRAUTERINE CONTRACEPTIVE DEVICE