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2-methyl-3-ethyl-4-phenyl-4-cyclohexene carboxylic acid (ORF 3858) was tested in Rana pipiens embryos to determine its effects on embryonic development and whether such effects are related to its estrogenicity. Development was blocked at cleavage gastrulation neurulation or hatching stages. Sensitivity to the compound increased as development proceeded. There was no correlation between the rate of embryonic uptake of the compound and its ability to block development. Receptor studies showed that uptake of estradiol and the estrogenic metabolites of ORF 3858 by frog embryonic cells did not involve specific high-affinity estrogen-binding components. Neither ORF 3858 nor estrogens modified embryonic nucleic acid synthesis. The compound appears to be unaltered by embryonic metabolism and seems to act as a zygolytic agent.

INHIBITION OF EMBRYONIC DEVELOPMENT IN RANA PIPIENS BY 2-METHYL-3-ETHYL-4-PHENYL-4-CYCLOHEXENE CARBOXYLIC ACID (ORF 3858)