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The effects of testosterone-filled PDS (polydimethylsiloxane) implants subcutaneously on circulating testosterone levels accessory sex gland function libido and spermatogensis in adult male rabbits were determined. Testis weights and total daily sperm production of rabbits receiving 215 sq. mm and 430 sq. mm testosterone implants for 90 days were significantly less than those of control animals. 5 of the 7 rabbits with 430 sq. mm testosterone implants were azoospermic. No significant differences were noted in sexual behavior scores accessory sex organ weight seminal fructose and citric acid concentrations or in plasma testosterone concentrations. Paired testis weight and total daily sperm production decreased significantly as the surface area of testosterone implants was increased from 100 to 800 sq. mm.

EFFECT OF TESTOSTERONE POLYDIMETHYLSILOXANE IMPLANTS UPON SPERM PRODUCTION, LIBIDO AND ACCESSORY SEX ORGAN FUNCTION IN RABBITS