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Summary. The postcoital antifertility activity of a series of triarylal- kenes and triarylalkanols with basic ether groups has been examined in mice and rats. The triarylalkenes were, in general, more potent than the others, and more potent orally than by injection. Apart from having a greater sensitivity than the mouse, the rat appears to give essentially the same information about relative potency and oestrogenic properties. Most compounds examined were weak to very weak oestrogens of an `impeded' type, not antioestrogenic in conventional tests, and many had a much higher antifertility potency than could be expected from their oestrogenic activity. The general pattern of results suggests that pre- implantation rather than postimplantation stages are affected, or more readily affected. The most potent compound examined (4h) was effec- tive in the mouse at an injected ED50 of 14\g=m\g/kg/dayafter coitus, with an oestrogenic (vaginal smear) ED50 of 250 times that dose. Several other compounds were effective at a dosage around 70 \g=m\g/kg/day.

ANTIFERTILITY ACTIVITIES IN THE MOUSE AND RAT OF TRIARYLALKENES AND TRIARYLALKANOLS WITH BASIC ETHER GROUPS