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Several publications have pointed out the deleterious action exerted by cytostatic drugs on human spermatogenesis (Heller, Flegeolli & Watson, 1963; Richter, Calamera, Morgenfeld, Kierszenbaum, Lavieri & Mancini, 1970; Fairley, Barri\l=e'\& Johnson, 1972). As many of the patients who receive cytostatic drugs often have a normal life expectancy, it was considered of interest to study the reappearance of spermatogenesis during variable periods of time after withdrawal of treatment. Van Thiel, Sherins, Myers & De Vita (1972) pointed out that in a group of such men in remission for 1 to 5 years after treatment with different drugs, persistent azoospermia was present in five out of seven of the treated individuals. This report concerns observations on a group of five patients with lymphoma who recovered spermatogenesis either partially or totally after treatment with Chlorambucil was suspended. The average age of the patients was 26 years. The daily dose of Chlorambucil was 2 to 10 mg, and the total accumulated dose is shown in Table 1. The effect of treatment was assessed by examination of ejaculates which were provided by masturbation following a period of 4 to 6 days abstinence. Macroand microscopic studies were performed within 1 hr of the specimen being obtained. The volume, turbidity, viscosity, pH, sperm concentration (\m=x\ l06/ml), motility and percentage of abnormal cells were recorded in each case. It can be seen from Table 1 that the five patients received a total dose of Chlorambucil which varied from 410 to 2600 mg. After withdrawal of treat¬ ment, all patients except Patient 5 developed azoospermia. In this patient, only

RECOVERY OF SPERMATOGENESIS IN PATIENTS WITH LYMPHOMA AFTER TREATMENT WITH CHLORAMBUCIL