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Summary. No significant effects on the duration of subsequent oestrous cycles, the duration of pseudopregnancy or on the other characteristics of pseudopregnancy were observed after hysterectomy in albino mice. In pregnancy, except for a slight transient effect on Day 10, the residual duration of luteal activity (as measured by the duration of the extrauterine weight loss and the interval to oestrus) was independent of the presence or absence of the uterus and pregnancy was maintained by a single contralateral ovary associated with an isolated non-pregnant horn. Loss of the placentae by hysterectomy or uterine evacuation on the 8th day of pregnancy had no influence on the duration of CL activity when compared with that of pseudopregnant animals. Thereafter, the duration of residual luteal activity declined to a near constant level from the 14th day onwards and this decline was accompanied by a reduction in the variability of the life of the CL normally seen in pseudopregnancy. Placental removal after the 14th day was followed by almost immediate cessation of luteal function which at no time (with the possible exception of the 18th day) continued for the remainder of the gestation period.

EFFECTS OF HYSTERECTOMY ON CORPUS LUTEUM ACTIVITY IN THE CYCLIC, PSEUDOPREGNANT AND PREGNANT MOUSE