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In a study with rats an attempt was made to measure the effect of antiandrogenic hormones on the metabolism of nonflagellate germ cells of the rat testis. Changes were observed as early as 4 days after the start of treatment. Long-term treatment with a progestin caused atrophy of the secondary sex glands and lowered sperm production with loss of libido. Sex glands and mating behavior returned to normal after treatment stopped. These findings are compatible with the hypothesis that progestins act as antigonadotropins which restrain the production of follicle stimulating hormone and interstitial cell-stimulating hormone enough to inhibit sperm production. Replacement of the endogenous androgen by administration of small amounts of testosterone prevented atrophy of the sex glands without restoring spermatogenesis. Based on the results of this study it seems possible to develop a male contraceptive with a dose of progestin sufficient to suppress sperm production and a dose of androgen sufficient to prevent atrophy of the accessory sex glands and loss of libido.

reproduction

EFFECTS OF SEX HORMONES ON GERMINAL CELLS OF THE RAT TESTIS: A RATIONALE FOR THE USE OF PROGESTIN AND ANDROGEN COMBINATIONS IN THE CONTROL OF MALE FERTILITY