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2 decidual cell-inducing stimuli were used to study the effects on t he passage of sodium-22 into the uterine lumen of albino Wistar rats. I n the 1st method .05 ml arachis oil was injected into the uterine lumen on Day 5 of pseudopregnancy or at metestrus. In the 2nd method a thread was placed unilaterally along the entire length of the lumen. An iv injection of 4-10 mcCi sodium-22 was given into a tail vein 25 minutes prior to perfusion to allow sodium-22 to become distributed and its concentration in the blood constant. Perfusate collected at 30-60 minutes after injection was used to determine the rate of passage of sodium-22. The oil injection on Day 5 of pseudopregnancy induced a decidual cell reaction and decreased sodium-22 content by about 50%. This effect was absent at metestrus. The thread in the uterine lumen for 1 day increased the rate markedly both in horns threaded on Day 5 of pseudopregnancy and at metestrus. When the thread was present for longer periods the uterus became unresponsive and the rate of passage of sodium-22 declined.

EFFECT OF DECIDUAL CELL-INDUCING STIMULI ON THE PASSAGE OF SODIUM INTO THE UTERINE LUMEN OF THE RAT