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Some evidence suggests that the male antifertility agent, 3-chloro-1,2-propanediol, may damage the vascular supply of the rat caput epididymidis and interfere with sperm maturation (Gunn, Gould & Anderson, 1969; Ericsson & Baker, 1970). Gunn et al. (1969) suggested that this chlorhydrin may act through interference with the secretion or utilization of glycerylphosphorylcholine within the epididymis. This proposal was considered because of the already established importance of glycerylphosphorylcholine within this context (Mann, 1964). However, if 3-chloro-1,2-propanediol were metabolized through pathways in which glycerol was the normal substrate, the first point at which to detect this proposed effect of chlorhydrin treatment would be in the total glycerol pool, itself, rather than by measurements of various phospholipid intermediates along the pathway from free glycerol to lecithin (Kennedy, 1961). The structural similarity of 3-chloro-1,2-propanediol to the glycerol molecule has led us to investigate the possibility that this chlorhydrin may act as a metabolic analogue of glycerol. This investigation was designed to measure the total glycerol concentrations throughout the excurrent duct system of the normal. adult rat and to determine if 3-chloro-1,2-propanediol treatment alters the total glycerol levels in any of the tissues responsible for sperm production, maturation and transport. A total of fifteen normal, mature, male Sprague-Dawley rats (350 to 500 g)

TOTAL GLYCEROL IN THE EXCURRENT DUCTS OF THE MALE RAT