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The rate of passage of iv-injected radioactive sodium into the uterine lumen of the rat has been measured in vivo to see whether it changes during the estrus cycle and under the influence of estrogen and progesterone. In one experiment radioactive-iodine-iodoantipyrine was also used. Nulliparous Wistar rats with 4-day cycles were used. Pseudopregnancy was induced by mating with vasectomized males. The uterus was exposed. Cotton ligatures were placed around the ends to avoid damage to blood vessels. A cunnula was pushed into the lumen. The uterine lumen was perfused with Locke solution under pressure at the rate of .4 ml per minute. Perfusion fluid was collected. An injection of 4 to 10 microcuries of radioactive sodium chloride was given into a tail vein and the perfusion begun 25 minutes later. The perfusate collected 30 to 60 minutes after the injection was used to determine the rate of passage of radioactive sodium into the lumen. It was found that radioactive-iodine-iodoantipyrine equilibrated with uterine fluid faster than radioactive sodium. The rate varied significantly at different stages in the estrus cycle and during the first 10 days of pregnancy or pseudopregnancy (p ranging from less than .01 to less than .05). Variations of a similar type could be produced in ovariectomized rats given physiological amounts of estrogen or estrogen plus progesterone. When the radioactive sodium was injected into the uterine lumen it passed only slowly into the general circulation. Other variations in the rate of passage appear to be due to changes brought about by the process of implantation and the growth of the implantation site. The comparactively slow rate o f passage of radioactive sodium into the lumen in these experiments indicates that there is a considerable barrier to the passage of sodium between the extracellular fluid and the uterine fluid.

PASSAGE OF SODIUM INTO THE UTERINE LUMEN OF THE RAT DURING THE SEXUAL CYCLE AND UNDER THE INFLUENCE OF STEROIDAL HORMONES