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Summary. Various triarylalkene derivatives which are weakly oestro- genic and not antioestrogenic at any dosage in conventional tests in mice and rats cause refractoriness to oestradiol for several weeks after injection in vaginal smear tests. The same compounds, administered in a single injection of 1 mg before mating, caused complete sterility for up to several weeks, although mating still occurred, sometimes at a slower rate than in controls. Daily injec- tions of effective doses (5 to 50 \g=m\g)produced similar effects, but reduced mating frequencies more severely. Oral administration was not followed by refractoriness to oestradiol. When a single dose of 1 mg was fed however, mating was normal but fertility was reduced by up to 85 % compared with controls. Daily oral dosing in the vehicle used (50% aqueous propylene glycol) or even of the vehicle alone upset the animals and reduced both mating and fertility.

COMPOUNDS EXHIBITING PROLONGED ANTIOESTROGENIC AND ANTIFERTILITY ACTIVITY IN MICE AND RATS