English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

The factors responsible for the immunological autonomy of the mammalian conceptus are poorly understood (Billingham, 1964). Pregnancy is unaffected by a variety of immunological insults. Immunization of the female against allogeneic paternal tissue has no effect on subsequent pregnancies (Lanman, Dinerstein & Fikrig, 1962). Previous studies (Currie, 1969) have confirmed the observations of Breyere & Barrett (1960) that pregnancy in the mouse induces a specific immunological defect involving paternal strain transplantation antigens and have extended them to show that this non-reactivity may be a form of antibody-mediated immunological enhancement. It is possible that this non- reactivity may play a part in protecting the conceptus from immune destruction. This communication describes a simple experiment designed to assess the effects of inter-strain murine pregnancy across a major histocompatability barrier on the immune status of females previously immunized against paternal tissue and to show whether pregnancy-induced non-reactivity can overcome specific immunity. Sixty virgin mice were used in this experiment and were 8-week-old females of A2G strain and highly inbred. Groups of these females were given intraperitoneal injections of CBA-strain male spleen cells, each mouse receiving 6 IO7 viable nucleated cells in 0-2 ml tissue culture medium 199. Control groups of females were given TC 199 only. Ten immunized and ten control females were not mated. The remaining immunized A2G females were mated 4 days later with male mice of proven fertility over a period of 5 days. One group of twenty females was mated with CBA-strain males and another similar group mated with A2G males. All the females were then weighed daily and only those with typical pregnancy weight gains 14 days after the start of the mating were used in the experiment. The male strain test graft was a CBA-strain-specific, transplantable fibrosar¬ coma. It is readily rejected in a predictable fashion by 100% of all A2G females inoculated. Four groups often A2G females were injected subcutaneous- ly in the shaved right flank with 0-2 ml of a 50% tumour mince in TC 199. The four groups injected were : non-immune non-pregnant A2G, immune non- pregnant A2G, immune 14-day pregnant by A2G males (intra-strain) and immune 14-day pregnant by CBA males (inter-strain). Maximum tumour

EFFECT OF INTERSTRAIN PREGNANCY ON THE IMMUNE STATUS OF FEMALE MICE SENSITIZED TO PATERNAL ANTIGENS