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An experiment in which various doses of human chorionic gonadotropin (HCG) were injected into rabbits before mating in order to determine whether a relationship existed between the dose level and the chromosomal abnormalities found in 6-day blastocysts is described. 11 rabbits were injected intravenously with doses of HCG varying between 75 and 300 i.u. immediate-y before mating with a fertile male. 110 corpora lutea were counted in the ovaries and 84 blastocysts were recovered on Day 6 from the 11 rabbits. Ovaries from rabbits receiving 300 i.u. HCG showed evidence of gross overstimulation with many large bright red unruptured follicles present. 90% of the blastocysts were examined chromosomally. The diploid number of chromosomes for the domestic rabbit is 44. The blastocyst in 1 rabbit who had received 75 i.u. HCG was a 43/44 mosaic with an XY chromosome complement in the cells with 44 chromosomes. 1 of the small acrocentric chromosomes was missing in the cells with 43 chromosomes and it was impossible to determine whether it was an autosome or the Y-chromosome. The blastocyst recovered from 1 animal who had been injected with 300 i.u. HCG had 44 chromosomes with a deletion of the short arms of 1 of the medium length submetacentric chromosomes. The sex chromosome complement of this blastocyst was also XY. To determine whether increased levels of gonadotropin administered during the time when the first polar spindle of the ovum is forming would adversely affect the chromosome complement 3 rabbits were injected with 75 i.u. HCG 4 hours after mating. No chromosomal abnormalities were found. The study of 6-day blastocysts recovered from rabbits treated with increased amounts of HCG during the time of ovum maturation gave no indication that excess chorionic gonadotropin adversely affects the chromosome constitution of developing ova.

THE CHROMOSOME COMPLEMENT OF BLASTOCYSTS FROM RABBITS INJECTED WITH VARIOUS DOSES OF HCG BEFORE OVULATION