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The mouse embryo can be cultivated in vitro from the two-cell stage to the blastocyst (Brinster, 1963, 1965) and from the fertilized one-cell stage to the two-cell stage (Whittingham & Biggers, 1967). Mouse embryos will not, however, develop in vitro from the fertilized one-cell stage to the blastocyst, but the one-cell embryo will develop into a blastocyst within the explanted Fallopian tube cultivated in vitro (Biggers, Gwatkin & Brinster, 1962). This information suggests that the Fallopian tube provides some environ¬ mental condition or nutrient that is not provided in the culture media which have been employed. The nature of this contribution of the Fallopian tube is not known, nor is it known whether the contribution to the embryo is the same in the mouse as in other species. If the Fallopian tube contribution is the same in different species, one-cell and/or two-cell mouse embryos should develop into blastocysts in the rabbit tube. To determine if the rabbit Fallopian tube would allow development of the early mouse embryo, oneand two-cell mouse embryos were transferred into rabbit Fallopian tubes and their subsequent development was recorded. The results of these experiments are reported here.

BLASTOCYST DEVELOPMENT OF MOUSE PRE-IMPLANTATION EMBRYOS IN THE RABBIT FALLOPIAN TUBE