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The oestrous response and subsequent fertility to natural service of 360 cyclic Merino ewes were studied following treatment with intravaginal sponges impregnated with three dose levels of 'Cronolone' (9\g=a\-fluoro-11\g=b\-hydroxy-17\g=a\-acetoxy-progesterone;Searle) and dried either in an oven or at ambient temperature. Sponges were inserted for 8 or 16 days and ninety were assayed for residual steroid after withdrawal. The rate of absorption of Cronolone was a linear function of the amount present at any time, and was affected by the method of drying (oven>air dried;;P 20>30 mg; P<0\m=.\002). The overall oestrous response with oven-dried sponges was higher than that with air-dried (P<0\m=.\05)but the slight difference in fertility

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THE RELATIONSHIP BETWEEN DOSE OF PROGESTAGEN AND METHOD OF PREPARATION OF INTRAVAGINAL SPONGES ON THEIR EFFECTIVENESS FOR THE CONTROL OF OVULATION IN THE EWE