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35 male rats injected subcutaneously with 1.0 mg estradiol 17beta for 10 days were successfully mated with normal female rats. No ova were found in the uteri or oviducts of these females on Days 3 and 4 of pregnancy. Ova in the 2 to 8-cell stages of cleavage were recovered from the oviducts or uteri of females mated with the 35 control males. Sufficient estrogen may have been transported in the semen of treated males to cause rapid transport of ova out of the oviduct and uterus. Histological studies of the testes and epididymide showed no abnormalities. Uterine sections of females mated with treated males showed hypertrophy and hyperplasia of both myometrium and endometrium.

THE EFFECT OF OESTROGEN ON THE FERTILITY OF THE RAT WHEN TRANSFERRED THROUGH THE SEMEN DURING MATING