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Twelve immature female monkeys were treated with varying amounts of pregnant mare's serum gonadotrophin (PMSG). Seven of these monkeys responded to PMSG treatment as shown by sex skin development, ovarian enlargement and withdrawal bleeding. These animals reached menarche between 23 and 26 months of age, almost 1 year earlier than untreated control monkeys. Five other animals did not show an initial response to PMSG treatment and attained puberty simultaneously with the untreated animals. It is suggested that increased production of oestrogen by the PMSG-stimulated ovaries may affect the hypothalamo-hypophysial axis in such a way that puberty is accelerated.

EVIDENCE OF PRECOCIOUS PUBERTY IN THE IMMATURE FEMALE RHESUS MONKEY (MACACA MULATTA) TREATED WITH PREGNANT MARE'S SERUM GONADOTROPHIN