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Summary. The effects on the pituitary lh levels of norethynodrel (20 \g=m\g/rat or approximately 0\m=.\1 mg/kg daily) and mestranol (1 \g=m\g/rator approximately 5 \g=m\g/kgdaily) administered subcutaneously singly or in combination for 10 days to intact female rats have been studied. lh was assayed by the ovarian ascorbic acid depletion method of Parlow (1958). Norethynodrel caused a significant increase in hypophysial lh stores without causing ovarian atrophy or reducing compensatory hypertrophy in unilaterally ovariectomized post-pubertal rats. Mestranol administra- tion, on the other hand, resulted in a significant ovarian atrophy without significant changes in the pituitary lh level, and also resulted in an inhibition ofcompensatory hypertrophy. The combined treatment result- ed in effects essentially similar to those observed in the mestranol- treated group. No evidence for potentiation between the two steroids was obtained. Data support the conclusion that when the two steroids are admin- istered together in the dosages used, the oestrogenic component is primarily involved in the pituitary lh inhibition.

EFFECTS OF NORETHYNODREL AND MESTRANOL ON PITUITARY LUTEINIZING HORMONE IN THE FEMALE RAT