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Rabbits ovariectomized 24 hr post coitum (p.c.) were injected i.m. with 2 mg or 4 mg 17\g=a\-hydroxyprogesteronecaproate daily. Pre\x=req-\ natal development was compared with that of control litters at 9 and 29 days, 5 days and 7 days p.c. The 2 mg treatment supported 26\m=.\4% pre-natal survival to 29 days p.c., most mortality occurring between 7 and 9 days. The 4 mg dose rate permitted 71 \m=.\0%survival to 29 days p.c. which was not significantly different from controls (81\m=.\5%).Blastocyst size at 5 days p.c. was not significantly affected by treatment but both ovariectomized groups showed slight retardation at 7 days when stage ofattachment was assessed by observation and by analysis ofblastocyst fluid for lactic acid. Attachment was least advanced in the group receiving the lower dose rate. In 29-day foetuses the degree ofossification of the femur was positively related to foetus weight. In control litters deposition ofcalcium and total ash components and relative decrease in water content were also further advanced in the larger foetuses, suggesting a general association of size and maturity.

OBSERVATIONS ON PREGNANCY IN INTACT RABBITS AND IN OVARIECTOMIZED RABBITS TREATED WITH 17 HYDROXYPROGESTERONE CAPROATE