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According to a proposal by Shelesnyak (1957, 1960), histamine is the chemical stimulus which causes deciduoma formation. Subsequent studies have also indicated that histamine is involved in the decidual reaction (cf. Marcus, Kraicer & Shelesnyak, 1963; Kracier, Marcus & Shelesnyak, 1963). A student laboratory manual, in an experiment to demonstrate the formation of deciduomata, specifies the use ofhistamine (Zarrow, 1960). However, in our experience histamine does not produce deciduomata in rats made pseudopregnant by sterile matings. Also, Finn & Keen (1962), using rats made pseudopregnant by electrical stimulation of the cervix, were unable to cause decidual reactions with histamine injections. Orsini (1963) was unable to produce decidual reactions in either the rat or the hamster with systemic injections of pyrathiazine, a histamine-releasing agent. Further, Banik, Kobayashi & Ketchel (1963) have shown that increasing or decreasing the histamine level in rats had no effect on nidation. In view of the many conflicting reports, we have reinvestigated the effect of intrauterine injections of histamine on the induction of deciduomata, using pregnant, pseudopregnant and nonpregnant rats. Adult female Sprague-Dawley rats weighing 200 to 250 g were placed in mating cages in the evening with normal males to obtain pregnant females, or with vasectomized males to obtain pseudopregnant females. Pregnancy or pseudopregnancy was ascertained by the presence of a vaginal plug early the following day, which was designated Day l. Dioestrous or oestrous females were obtained by vaginal smears taken through at least two consecutive normal

INABILITY OF HISTAMINE TO INDUCE DECIDUOMATA IN PREGNANT AND PSEUDOPREGNANT RATS