English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Pro

Presents the zaia usage as premium feature

ZAIA

Presents AI Discovery search usage as a premium feature

AI Discovery

Presents AI Discovery explain and summary usage as a premium feature

Content Analysis

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Presents the pdf analysis as premium feature

PDF Analysis

1500 Top-up

3000 Top-up

Zendy Basic

2500 Top-up

Zendy Unlimited

Presents the access of premium content as premium feature

Premium Content

Among all the androgens that stimulate or control the development and maintenance of body composition, testosterone could be the most well known and important due to its linkage to many diseases, including the metabolic syndrome, type 2 diabetes, and cardiovascular disease. The detailed mechanisms of how testosterone functions in health and disease, however, remain unclear. During the past several decades, the successful cloning of the androgen receptor (AR) and its coregulators and establishment of AR transgenic and knockout animal models have led to rapid development in this field of study. The two thematic reviews in this issue of the Journal of Endocrinology provide a timely and useful guide and source of information to discuss the current knowledge of the metabolic and vascular actions of testosterone involvement in these androgen-related disorders. They described the mechanisms of relationships between testosterone and metabolic disease and how testosterone regulates vascular function and inflammation with a comprehensive summary of updated androgen-AR findings. As more research and clinical trials have put efforts into the study of how testosterone functions in these diseases, it is expected that the roles of testosterone and its actions will become clearer in the near future.

Beyond the male sex hormone: deciphering the metabolic and vascular actions of testosterone