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3 Lucie Evenepoel 1,2 , Raphaël Helaers 2 , Laurent Vroonen 3 , Selda Aydin 4 , Marc Hamoir 5 , 4 Dominique Maiter, Miikka Vikkula, Alexandre Persu 5 6 1 Pole of Cardiovascular Research, Institut de Recherche Expérimentale et Clinique, Université catholique de 7 Louvain, Brussels, Belgium, 2 Human Molecular Genetics, de Duve Institute, Université catholique de Louvain, 8 Brussels, Belgium, 3 Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of 9 Liège, Domaine Universitaire du Sart-Tilman, Belgium, 4 Pathology Department, Cliniques universitaires Saint 10 Luc, Université catholique de Louvain, Brussels, Belgium, 5 Otolaryngology Department, Cliniques 11 Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium, 6 Endocrinology Department, 12 Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium, 7 Cardiology 13 Department, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium. 14 15 The authors declare no conflict of interest. 16

KIF1B and NF1 are the most frequently mutated genes in paraganglioma and pheochromocytoma tumors