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In a recent case study, we have reported a proof-ofconcept that a combination of metformin and oral contraceptives treats early-stage endometrial cancer (EC) in women with polycystic ovary syndrome (PCOS). Although metformin-induced metabolic effects in PCOS patients have been investigated, it is not known whether this therapeutic drug has a direct effect on the endometria and further regulates glycolysis and mitochondrial function in PCOS patients with endometrial hyperplasia and carcinoma.

Metformin directly alters key glycolytic enzyme protein expression and mitochondrial function in the endometria of PCOS patients