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Adipose tissue is a metabolic active tissue that secretes multiple metabolically important proteins known as ‘adipokines’. Some adipokines could be relate to insulin resistance which has a causal role in Type 2 diabetes mellitus (T2DM) and its cardiovascular complications. Adiponectin, an adipocyte-secreted protein, is known to have anti-atherogenic, anti-inflammatory and antidiabetic properties and its serum levels are decreased in obesity, T2DM, and coronary artery disease. Different polymorphisms have been identified in humans and examined for their possible association with insulin resistance indexes and circulating adiponectin concentrations. Variants of ADIPOQ have been inconsistently associated with adiponectin levels or diabetes in diverse populations.

endocrine abstracts

Association between +276 G[gt]T polymorphism of the adiponectin gene (ADIPOQ) and insulin resistance in Ukrainian patients with type 2 diabetes mellitus (T2DM)