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Seven patients with SCD (age : 24.2 +/4.5 years) and short stature (HtSDS = 2.5 +/0.4) and history of severe and recurrent vaso-occlusive crisis ( at least 3 in the past 3 years) were studied. All were transfusion – dependent, with full pubertal development (Tanner’s stage 5) (euogonadal). They were regularly transfused since early childhood and underwent chelation therapy using desferrioxamine which was replaced by deferasirox for the last 4 -5 years.

Pituitary abnormalities in short adolescents and young adults with sickle-cell disease and recurrent vaso-occlusive crisis