English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Receptor endocytosis plays an important role in regulating the responsiveness of cells to specific hormones. Phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2] has been shown to be critical for many endocytic processes including the internalization of G protein-coupled receptors (GPCRs). Our aim in this study was to compare the effect of two distinct plasma membrane PtdIns(4,5)P2 depletion methods on GPCR internalization in HEK 293 cells. We used bioluminescence resonance energy transfer (BRET) and confocal microscopy to determine the effectiveness of our depletion methods and to follow the endocytosis of β2 adrenergic receptor (β2AR).

The effect of hormone-induced PtdIns (4, 5) P2 depletion on endocytosis suggests the importance of local regulation of inositol lipid signalling