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INRODUCTION Hyponatraemia is defined as a sodium concentration below 135 mmol/L. Syndrome of inappropriate antidiuretic hormone (SIADH) secretion is one of the causes of hyponatraemia with a low serum osmolality. SIADH results from the combination of water retention and loss of sodium and potassium [1,2]. The causes of SIADH include: meningitis, head injury, subarachnoid hemorrhage, cancer, infections, medications, hypothyroidism and sarcoidosis. Treatment options for SIADH include fluid restriction, salt administration, demeclocycline, lithium and use of vasopressin receptor antagonists [1,3,4]. The importance of hyponatraemia correction rate cannot be underestimated to avoid the risk of development of osmotic demyelination syndrome.

Treatment of hyponatraemia with vasopressin receptor 2 antagonists (V2RA): case series