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These results indicate that our invasion signature is enriched for the epithelial-to-mesenchymal (EMT) markers (CDH1, ESRP1, EPCAM, PERP, CTNNB1, ZEB1) and genes involved in invasion pathway (S100P, SPP1, NTS). Therefore, in pituitary tumorigenesis EMT likely occurs within a specific genetic context and may be related to their increased local invasion and aggressive phenotype which may contribute to treatment resistance. We have also demonstrated that lack of AIP plays a critical role in cellular invasion; these changes may recapitulate the in vivo situation. This study has important implications for our understanding of the molecular basis of AIPpos pituitary tumourigenesis. Identified genes may predict the invasive potential of these tumours and provide new opportunity to develop therapies. 10. References 1 Daly AF, et al (2010) J.Clin.Endocrinol.Metab., 95, E373-E383. 2. Chahal, H, et al (2012) J.Clin.Endocrinol.Metab., 97, E1411-1420.

Invasion signature' revealed by the analysis of AIP positive and AIP mutation negative human pituitary adenomas