Open AccessInvolvement of the gp130 cytokine transducer in MtT/S pituitary somatotroph tumour development in an autocrine-paracrine model
Author(s) -
Mariana Graciarena,
A Carbia-Nagashima,
Chiara Onofri,
Carolina Perez-Castro,
Damiana Giacomini,
Ulrich Renner,
GK Stalla,
Eduardo Arzt
Publication year - 2004
Publication title -
european journal of endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.897
H-Index - 148
eISSN - 1479-683X
pISSN - 0804-4643
DOI - 10.1530/eje.0.1510595
Subject(s) - autocrine signalling , glycoprotein 130 , paracrine signalling , mtt assay , cell culture , cytokine , biology , cell growth , transfection , endocrinology , interleukin 6 , cell , microbiology and biotechnology , cancer research , medicine , chemistry , receptor , immunology , biochemistry , genetics
gp130 cytokines are placed as auto-paracrine regulators of pituitary function, since they, as well as their receptors, have been shown to be expressed in and to act in normal and tumoral anterior pituitary cells. The objective of this work was to study their involvement in a model that shows the interaction between different cellular types that participate in a tumorigenic process.
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