Open AccessPotent thyrotrophin receptor-blocking antibodies: a cause of transient congenital hypothyroidism and delayed thyroid development
Author(s) -
Carol Evans,
NJ Jordan,
G Owens,
D M Bradley,
Marian Ludgate,
R John
Publication year - 2004
Publication title -
european journal of endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.897
H-Index - 148
eISSN - 1479-683X
pISSN - 0804-4643
DOI - 10.1530/eje.0.1500265
Subject(s) - transplacental , endocrinology , medicine , antibody , receptor , blocking antibody , in utero , thyrotropin receptor , thyroid , hormone , endogeny , fetus , pregnancy , biology , graves' disease , immunology , genetics , placenta
We describe an infant with surprisingly severe neonatal hypothyroidism due to transplacental passage of thyrotrophin receptor (TSH-R)-blocking antibodies (TBAb).
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