Open AccessAromatase and breast cancer: W39R, an inactive protein
Author(s) -
Céline Nativelle-Serpentini,
Sophie Lambard,
GE Seralini,
Pascal Sourdaine
Publication year - 2002
Publication title -
european journal of endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.897
H-Index - 148
eISSN - 1479-683X
pISSN - 0804-4643
DOI - 10.1530/eje.0.1460583
Subject(s) - aromatase , estrone , recombinant dna , medicine , endocrinology , androstenedione , transfection , biology , estrogen , mutant , enzyme , breast cancer , hormone , cancer , androgen , gene , biochemistry
Aromatase (CYP19) catalyzes the conversion of androgens into estrogens. It is in particular involved in development, reproduction and breast cancer. One of its polymorphisms, W39R localized in the N-terminal region of CYP19, significantly decreases breast cancer risk among Japanese women and was chosen for this study. In this work, we studied the structure-function relationships between W39R polymorphism and CYP19 enzyme activity.
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