Open AccessGhrelin drives GH secretion during fasting in man
Author(s) -
Muller Af,
SW Lamberts,
J. A. M. J. L. Janssen,
Leo J. Hofland,
PV Koetsveld,
Martin Bidlingmaier,
CJ Strasburger,
Ezio Ghigo,
AJ van der Lely
Publication year - 2002
Publication title -
european journal of endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.897
H-Index - 148
eISSN - 1479-683X
pISSN - 0804-4643
DOI - 10.1530/eje.0.1460203
Subject(s) - ghrelin , medicine , endocrinology , secretagogue , growth hormone secretagogue receptor , pegvisomant , stimulation , receptor , hormone , growth hormone , acromegaly
In humans, fasting leads to elevated serum GH concentrations. Traditionally, changes in hypothalamic GH-releasing hormone and somatostatin release are considered as the main mechanisms that induce this elevated GH secretion during fasting. Ghrelin is an endogenous ligand of the GH secretagogue receptor and is synthesized in the stomach. As ghrelin administration in man stimulates GH release, while serum ghrelin concentrations are elevated during fasting in man, this increase in ghrelin levels might be another mechanism whereby fasting results in stimulation of GH release.
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