Open AccessRetention of dopamine 2 receptor mRNA and absence of the protein in craniospinal and extracranial metastasis of a malignant prolactinoma: a case report
Author(s) -
Juliane Winkelmann,
Uberto Pagotto,
Marily Theodoropoulou,
Klaus Tatsch,
Wolfgang Saeger,
Annette Müller,
Thomas Arzberger,
Ludwig Schaaf,
EM Schumann,
Claudia Trenkwalder,
GK Stalla
Publication year - 2002
Publication title -
european journal of endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.897
H-Index - 148
eISSN - 1479-683X
pISSN - 0804-4643
DOI - 10.1530/eje.0.1460081
Subject(s) - prolactinoma , dopamine receptor d2 , dopamine , metastasis , medicine , dopamine receptor , endocrinology , in situ hybridization , immunohistochemistry , pathology , biology , messenger rna , prolactin , cancer research , cancer , gene , biochemistry , hormone
The case presented here describes the clinical evolution of a malignant prolactinoma with occurrence of intra- and extra-cranial metastases. In this case, the presence of dopamine 2 receptor (D2R) was studied at the mRNA and protein level, in order to understand the pathological background of the resistance to treatment with different dopamine agonists.
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