Open AccessGlucose-regulated pulsatile insulin release from mouse islets via the K(ATP) channel-independent pathway
Author(s) -
Johanna Westerlund,
Henrik Ortsäter,
Fredrik Palm,
Tea Sundsten,
Peter Bergsten
Publication year - 2001
Publication title -
european journal of endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.897
H-Index - 148
eISSN - 1479-683X
pISSN - 0804-4643
DOI - 10.1530/eje.0.1440667
Subject(s) - diazoxide , medicine , endocrinology , insulin , l glucose , basal (medicine) , stimulation , biology , chemistry , islet
Regulation of insulin release by glucose involves dual pathways, including or not inhibition of ATP-sensitive K(+) channels (K(ATP) channels). Whereas the K(ATP) channel-dependent pathway produces pulsatile release of insulin it is not clear whether the independent pathway also generates such kinetics.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom