Open AccessDecreased ligand affinity rather than glucocorticoid receptor down-regulation in patients with endogenous Cushing's syndrome
Author(s) -
N. A. T. M. Huizenga,
WW de Herder,
JW Koper,
Pieter de Lange,
D AJ v Lely,
Brinkmann Ao,
FH de Jong,
SW Lamberts
Publication year - 2000
Publication title -
european journal of endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.897
H-Index - 148
eISSN - 1479-683X
pISSN - 0804-4643
DOI - 10.1530/eje.0.1420472
Subject(s) - glucocorticoid receptor , endocrinology , medicine , endogeny , receptor , glucocorticoid , ligand (biochemistry) , dexamethasone , cushing syndrome , hydrocortisone , chemistry
Glucocorticoids (GCs) serve a variety of important functions throughout the body. The synthesis and secretion of GCs are under the strict influence of the hypothalamo-pituitary-adrenal axis. The mechanisms of action of GCs are mediated by the intracellular glucocorticoid receptor (GR). Over the years, many studies have been performed concerning the regulation of GR expression by GC concentrations.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom