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the releaseof growth hormone (GH) from pituitary cells, althoughtheir potency was rather weak (1). Further studiesbased on conformational energy calculations in con-junction with peptide chemistry modications andbiological activity testing, led in 1984 to the develop-ment of several more potent peptides, including growthhormone-releasing peptide-6 (GHRP-6) (2). This hexa-peptide was shown to be a potent releaser of GH both

Ghrelin: a step forward in the understanding of somatotroph cell function and growth regulation