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The aim of this study was to follow changes in body composition, estimated by dual-energy X-ray absorptiometry (DXA), in relation to changes in leptin during the first year of GH therapy in order to test the hypothesis that leptin is a metabolic signal involved in the regulation of GH secretion in children.

Changes in body composition and leptin levels during growth hormone (GH) treatment in short children with various GH secretory capacities