Open AccessSingle nucleotide polymorphisms in the intergenic region between metformin transporter OCT2 and OCT3 coding genes are associated with short-term response to metformin monotherapy in type 2 diabetes mellitus patients
Author(s) -
Linda Zaharenko,
Ineta Kalniņa,
Kristine Geldnere,
Ilze Konrāde,
Solveiga Grı̄nberga,
Jozef Židzik,
Martin Javorský,
Aivars Lejnieks,
Liene Ņikitina-Zaķe,
Dāvids Frīdmanis,
Raitis Pečulis,
Ilze Radoviča-Spalviņa,
Dace Hartmane,
Osvalds Pugovičs,
Ivan Tkáč,
Lucia Klimčáková,
Valdis Pīrāgs,
Jānis Kloviņš
Publication year - 2016
Publication title -
european journal of endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.897
H-Index - 148
eISSN - 1479-683X
pISSN - 0804-4643
DOI - 10.1530/eje-16-0347
Subject(s) - metformin , organic cation transport proteins , single nucleotide polymorphism , type 2 diabetes , medicine , diabetes mellitus , endocrinology , gene , genetics , biology , oncology , pharmacology , transporter , genotype
High variability in clinical response to metformin is often observed in type 2 diabetes (T2D) patients, and it highlights the need for identification of genetic components affecting the efficiency of metformin therapy. Aim of this observational study is to evaluate the role of tagSNPs (tagging single nucleotide polymorphisms) from genomic regions coding for six metformin transporter genes with respect to the short-term efficiency.
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