Open AccessGenetic variation at the IGF1 locus shows association with post-stroke outcome and to circulating IGF1
Author(s) -
N. David Åberg,
Sandra Olsson,
Daniel Åberg,
Katarina Jood,
Tara M. Stanne,
Michael Nilsson,
Christian Blomstrand,
Johan Svensson,
Jörgen Isgaard,
Christina Jern
Publication year - 2013
Publication title -
european journal of endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.897
H-Index - 148
eISSN - 1479-683X
pISSN - 0804-4643
DOI - 10.1530/eje-13-0486
Subject(s) - single nucleotide polymorphism , medicine , stroke (engine) , modified rankin scale , allele , odds ratio , snp , locus (genetics) , minor allele frequency , ischemic stroke , genotype , gene , genetics , biology , ischemia , engineering , mechanical engineering
In humans, serum IGF1 (s-IGF1) is associated with outcome after ischemic stroke (IS). Therefore variation at the IGF1 locus could also associate with both IS and s-IGF1. We investigated whether genetic variation at the IGF1 locus is associated with i) s-IGF1, ii) IS occurrence, iii) IS severity, and iv) post-stroke outcome.
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