Open AccessGenotypes associated with lipid metabolism contribute to differences in serum lipid profile of GH-deficient adults before and after GH replacement therapy
Author(s) -
Edna J. L. Barbosa,
Camilla A M Glad,
Anna G Nilsson,
Helena Filipsson Nyström,
G. Götherström,
PerArne Svensson,
Isabela Vinotti,
BengtÅke Bengtsson,
Staffan Nilsson,
César Luiz Boguszewski,
Gudmundur Johannsson
Publication year - 2012
Publication title -
european journal of endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.897
H-Index - 148
eISSN - 1479-683X
pISSN - 0804-4643
DOI - 10.1530/eje-12-0263
Subject(s) - medicine , endocrinology , single nucleotide polymorphism , snp , apolipoprotein b , peroxisome proliferator activated receptor gamma , lipid metabolism , genotype , cholesterylester transfer protein , biology , lipid profile , apolipoprotein e , cholesterol , peroxisome proliferator activated receptor , gene , genetics , lipoprotein , receptor , disease
GH deficiency (GHD) in adults is associated with an altered serum lipid profile that responds to GH replacement therapy (GHRT). This study evaluated the influence of polymorphisms in genes related to lipid metabolism on serum lipid profile before and after 1 year of GHRT in adults.
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