Open AccessElevated plasma glucose-dependent insulinotropic polypeptide associates with hyperinsulinemia in metabolic syndrome
Author(s) -
Salvatore Calanna,
Francesca Urbano,
Salvatore Piro,
Rose Maria Zagami,
Antonino Di Pino,
L. Spadaro,
Francesco Purrello,
Agata Maria Rabuazzo
Publication year - 2012
Publication title -
european journal of endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.897
H-Index - 148
eISSN - 1479-683X
pISSN - 0804-4643
DOI - 10.1530/eje-11-0765
Subject(s) - medicine , endocrinology , incretin , insulin resistance , hyperinsulinemia , insulin , glucose tolerance test , type 2 diabetes , area under the curve , glucagon , glucagon like peptide 1 , diabetes mellitus , impaired glucose tolerance , pancreatic hormone
Metabolic syndrome (MS) is a high-risk condition for type 2 diabetes, a disease characterized by insulin resistance and insulin secretion abnormalities. Insulin resistance has been widely characterized in MS subjects while insulin secretion has been poorly investigated. The present study was hence undertaken to further investigate the α and β cell function and entero-insular axis in this pre-diabetic condition.
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