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Objective  Increase of resistin and/or reduction of adiponectin have been implicated in the development of insulin resistance following weight gain. We aimed to study this prospectively in humans.    Design  Prospective and interventional with parallel control group.    Methods  Twelve healthy men and six healthy women (age 26±6.6 years) and an age-matched control group were recruited. Subjects in the intervention group aimed for a bodyweight increase of 5–15% by doubling the baseline caloric intake by eating at least two fast food-based meals a day in combination with adoption of a sedentary lifestyle for 4 weeks.    Results  Bodyweight increased from 67.6±9.1 to 74.0±11 kg, P  10 mg/l were disregarded.    Conclusions  Hyperalimentation reduces insulin sensitivity when weight gain of 9% was combined with reduction of exercise. However, the levels of resistin and adiponectin were unaffected by the intervention, while CRP levels increased within this short time period suggesting that low-grade inflammation can occur early in the process of developing a metabolic syndrome.

european journal of endocrinology

Weight gain by hyperalimentation elevates C-reactive protein levels but does not affect circulating levels of adiponectin or resistin in healthy subjects