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Polycystic ovary syndrome (PCOS) is associated with an increased risk of cardiovascular disease in women. Hyperhomocysteinemia (H-Hcy) is closely related to arterial stiffness (AS) in patients with cardiovascular disease. This study aimed to investigate the relationship between serum homocysteine(Hcy) level and brachial-ankle pulse wave velocity (baPWV) in Chinese women with PCOS. A total of 124 PCOS women were enrolled and divided into two groups according to their baPWV values: normal, baPWV &lt; 1400 cm/s and high AS, baPWV ≥ 1400 cm/s. Univariate analysis was performed to investigate the relative factors for baPWV, and multiple regression analysis was used to evaluate the association of Hcy with baPWV. The group with high AS ( n  = 35) had higher Hcy levels than the other group ( n  = 89;  P &lt;  0.05). Moreover, univariate analysis revealed that serum Hcy was positively correlated with baPWV ( r  = 0.133,  P &lt;  0.01). In multiple regression analysis, the age-adjusted serum Hcy level was positively correlated with baPWV ( β =  0.201,  P &lt;  0.01). It remained positively associated with baPWV ( β  = 0.145,  P &lt;  0.01) after further adjustments for age, BMI, PCOS duration, systolic blood pressure, and homeostasis model assessment-insulin resistance as well as several other factors correlated with baPWV. Our results demonstrated that H-Hcy was significantly and independently related to elevated baPWV, suggesting that Hcy might play a role in the pathologic process of AS in women with PCOS. Further researches with more subjects are needed to explore whether Hcy would be a promising biomarker for the stratification management of PCOS women.

Homocysteine is an indicator of arterial stiffness in Chinese women with polycystic ovary syndrome