English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Objective: The aim of this study is to clarify, in girls with premature pubarche (PP), the influence of premature androgenization on the prevalence of polycystic ovary syndrome (PCOS).  Design and patients: Ninety-nine PP girls, 63 who developed PCOS and 36 who did not develop PCOS, were cross-sectionally included. Clinical, anthropometric, and metabolic parameters were evaluated to find predictive factors of PCOS.  Results: Young females with PP showed a PCOS prevalence of 64% and showed higher prevalence of familial history of diabetes (p= 0.004) and lower prevalence of underweight (p= 0.025) than PP-NO-PCOS. In addition, girls with PP-PCOS showed higher BMI (p&lt;0.001), waist circumference (p&lt;0.001), total testosterone (p= 0.026), visceral adiposity index (VAI) (p= 0.013), total cholesterol (p&lt;0.001), LDL-cholesterol (p&lt;0.001), non-HDL-cholesterol (p&lt;0.001) and lower age of menarche (p=0.015), ISI-Matsuda (p&lt;0.001), DIo (p= 0.002), HDL-cholesterol (p= 0.026) than PP-NO-PCOS. Multivariate analysis showed that WC (p=0.049), ISI-Matsuda (p&lt;0.001), oral disposition index (DIo) (p&lt;0.001), VAI (p&lt;0.001), total testosterone (p&lt;0.001) and LDL-cholesterol (p&lt;0.001) are independent predictive factors for PCOS in girls with PP.  Conclusions: Our study established a strong association between multiple risk factors and development of PCOS in PP girls. These risk factors are predominantly related to the regulation of glucose, lipid, and androgen metabolism. Among these factors, WC, ISI-Matsuda, DIo, VAI, total testosterone and LDL-cholesterol predict PCOS.

Predictive factors of polycystic ovary syndrome in girls with precocious pubarche