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Parathyroid hormone (PTH) generally has a positive effect and Dexamethasone (DEXA) a negative effect on bone formation. In the present project, we have investigated the impact of treatment of parathyroid hormone (PTH) and Dexamethasone (DEXA) on global miRNA expression in primary human bone (HOB) cells by second generation sequencing of small RNA. Micro-RNAs (miRNAs), small non-coding RNAs, identified as regulators in various biological processes, have been shown to be involved in human development and disease. By binding to complementary RNA strands, they efficiently affect mRNA levels and/or mRNA translation. We have previously used miRNA LNA arrays to assess global miRNA expression in human bone cells, and have identified approximately 90 miRNAs with significant expression levels, and have in addition identified a subset of miRNAs exhibiting interindividual and/or gender differences in expression. We have also shown significant correlations between miRNA and mRNA expression of genes involved in bone metabolism in human bone cells.

bone abstracts

Primary Human Bone Cells treated with Parathyroid Hormone or Dexamethasone show Effects on micro-RNA Expression Patterns Assessed by Second Generation Sequencing