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D18 Figure 2: Schematic of the model used for investigating t h e e f f e c t o f e l e v a t e d SOSTDC1 on bone formation in C57BLKaLwRij mice. SOSTDC1 was injected via the tail vein. Bone volume (BV) was analysed using μCT and OB/OC numbers assessed via standard histomorphometry. D0 D2 D4 D12 D16 A novel antagonist of the canonical Wnt-signalling pathway, SOSTDC1, is expressed in an experimental model of myeloma and suppresses bone formation

A novel antagonist of the canonical Wnt-signalling pathway, Sostdc1, is expressed in experimental models of myeloma and suppresses bone formation