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This work was partially supported by the AO Foundation (Davos, Switzerland) and by the grants from AOSpine Japan.  None of the authors has any financial interest with any of the commercial entities.  All authors state that they have no conflicts of interest. Discussions  Management of local osteoporotic lesions is a clinical difficult problem, and intravenous administration of bisphosphonates (BPs) has a limited effect for local osteoporotic or osteolytic lesion.

Direct administration of zoledronate acid improves bone structure in local osteoporotic lesion of ovariectomized rats