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Myosin V is a two-headed processive motor protein that walks in ahand-over-hand fashion along actin filaments. When it encounters a filamentbranch, formed by the Arp2/3 complex, it can either stay on the straight motherfilament, or switch to the daughter filament. We study both probabilities usingthe elastic lever arm model for myosin V. We calculate the shapes and bendingenergies of all relevant configurations in which the trail head is bound to theactin filament before Arp2/3 and the lead head is bound either to the mother orto the daughter filament. Based on the assumption that the probability for ahead to bind to a certain actin subunit is proportional to the Boltzmann factorobtained from the elastic energy, we calculate the mother/daughter filamentbranching ratio. Our model predicts a value of 27% for the daughter and 73% forthe mother filament. This result is in good agreement with recent experimentaldata.

Myosin V passing over Arp2/3 junctions: branching ratio calculated from the elastic lever arm model