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This article presents the first direct comparison of level of response (LR)-based prospective models in two generations of the same families. To accomplish this, we describe results from the first prospective evaluation of potential mediators of how an earlier low LR to alcohol relates to adverse alcohol outcomes in offspring from the San Diego Prospective Study (SDPS).

Comparison Across Two Generations of Prospective Models of How the Low Level of Response to Alcohol Affects Alcohol Outcomes