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Apoptosis is a highly organized form of cell death that plays an important regulatory role in many biological processes. The relationship between the two classical signalling pathways of apoptosis, the “death receptor” and “mitochondrial” pathways, was only vaguely appreciated until 1998, when death receptor pathway-mediated activation of the mitochondrial pathway was clearly demonstrated for the first time. The “type I/type II” model of death receptor-mediated apoptosis was proposed and subsequently adopted for use in categorizing cells according to the involvement of the mitochondrion during death receptor-induced apoptosis. Since that time, however, different interpretations of the type I/type II cell definition have appeared in the literature and, consequently, the meaning of type I and type II cells has become less clear. L’apoptose est une forme de mort cellulaire tres structuree qui joue un role important de regulation dans un grand nombre de processus biologiques. La relation entre les deux voies de signalisation traditionnelles de l’apoptose, la voie des « recepteurs de mort » et la voie mitochondriale, n’etait connue que vaguement avant 1998, l'annee ou l’activation de la voie mitochondriale par l’intermediaire de la voie des recepteurs de mort a ete clairement demontree pour la premiere fois. Le modele « type I / type II » d’apoptose par l’intermediaire des recepteurs de mort a ete propose puis adopte aux fins de categorisation des cellules en fonction de la participation des mitochondries a cette apoptose. Depuis, differentes interpretations ont toutefois ete formulees dans des ouvrages scientifiques quant a la definition des cellules de type I et de type II et, par consequent, la signification de « cellules de type I » et de « cellules de type II » est devenue moins evidente.

CLEAR AS MUD: THE TYPE I/TYPE II MODEL FOR DEATH RECEPTOR-INDUCED APOPTOSIS